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Evidence is increasing that all addiction without exception is related to difficulties with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you need to err on the side of caution and permit the FDA do its job and demand some research be done so that the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies are in business to make money and that they would say anything to keep people on their own medications.

Researchers found out that participants using this drug for any year, dropped a few pounds within four weeks and have kept the load off through the entire 56 weeks with the study. Contrave is really a combination with the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them more efficient and safer.

Combo-pilling is the newest fad or even better the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is becoming popular could be the fact that by right now there are no long term prescription weightloss pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug could also raise hypertension and heart rate, and really should not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high blood pressure, and also by you are not heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients to the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.


After a patient has admitted inside a rehab centre to the treatment of opiate detoxification, medical practitioner at the same time start detoxifying the patients body. The patient would feel pain in the event the treatment starts when they are in full senses, so usually an anesthesia injection has injected with their body making them get to sleep. After the patient had opted into deep sleep because of the affect of the injection opium blockade will be used for narcotics medication. These opium blockade injections are best of it is kind for narcotics medication because they are very helpful in eradication of symptoms like anti-nausea and muscle calmness. These are intravenous injections which help in curing the patients through the harmful toxins effects. For a speedy recovery and medication of opiate detoxification, opium blockade injections like nalaxone, naltrexone etc are employed which makes an easy detoxification from narcotics as well as the patient has discharged from your rehab after full a couple of days of treatment.